Isochore Evolution in Mammals: A Human-Like Ancestral Structure
نویسندگان
چکیده
منابع مشابه
Isochore evolution in mammals: a human-like ancestral structure.
Codon usage in mammals is mainly determined by the spatial arrangement of genomic G + C-content, i.e., the isochore structure. Ancestral G + C-content at third codon positions of 27 nuclear protein-coding genes of eutherian mammals was estimated by maximum-likelihood analysis on the basis of a nonhomogeneous DNA substitution model, accounting for variable base compositions among present-day seq...
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The genomes of mammals and birds show dramatic variation in base composition over large scales, the so called isochore structure of the genome. The origin of isochores is still controversial: various neutral and selectionist models have been proposed--and criticized--since the discovery of isochores in the 1970s. The availability of complete mammalian genomes has yielded new opportunities for a...
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BACKGROUND The isochore, a large DNA sequence with relatively small GC variance, is one of the most important structures in eukaryotic genomes. Although the isochore has been widely studied in humans and other species, little is known about its distribution in pigs. PRINCIPAL FINDINGS In this paper, we construct a map of long homogeneous genome regions (LHGRs), i.e., isochores and isochore-li...
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Determining the evolutionary relationships between fossil hominid groups such as Neanderthals and modern humans has been a question of enduring interest in human evolutionary genetics. Here we present a new method for addressing whether archaic human groups contributed to the modern gene pool (called ancient admixture), using the patterns of variation in contemporary human populations. Our meth...
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Eukaryotic genomes are compositionally heterogeneous, that is, composed by regions that differ in guanine-cytosine (GC) content (isochores). The most well documented case is that of vertebrates (mainly mammals) although it has been also noted among unicellular eukaryotes and invertebrates. In the human genome, regarded as a typical mammal, this heterogeneity is associated with several features....
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ژورنال
عنوان ژورنال: Genetics
سال: 1998
ISSN: 1943-2631
DOI: 10.1093/genetics/150.4.1577